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It is our goal to apply advanced nanomanufacturing techniques for the development of biomedical micro and nano-devices. We employ biomaterials such as biodegradable polymers to fabricate scaffolds and nanostructured polymers for drug delivery, nerve repair, and tissue growth. By precise control of spatial and temporal distributions of biological factors in the 2- or 3-dimensional micro/nanostructures (e.g. scaffolds), we can study stem cell behavior in precisely designed complex 3D microenvironments and create hybrid tissue structures for on-demand transplantation.
Silicon-based nano/micro-fabrication techniques have also been applied in the development of DNA microchips (PCR), protein micro-chips, and catheter probes in collaboration with researchers at the UT MD Anderson Cancer Center, UT Health Science Center in Houston, and UT Health Science Center in San Antonio.
Research projects in this area have been supported by the US Department of Defense through the UT MD Anderson Cancer Center, the Young Investigator award from the Office of Naval Research, and two seed grants from the UT Biomedical Engineering/Whitaker Foundation.
Representative Publications:
Y. Lu, G. Mapili, G. Suhali, S.C. Chen, K. Roy, “A Digital Micro-mirror Device (DMD)-based System for the microfabrication of Complex, Spatially Patterned Tissue Engineering Scaffolds”, Journal of Biomedical Materials Research A, Vol. 77A (2), pp 396-405, 2006.
H. W. Kang, H. Lee, S.C. Chen, and A. J. Welch, “Enhancement of Bovine Bone Ablation Assisted by a Transparent Liquid Layer on Target Surface”, IEEE Journal of Quantum Electronics, in press, 2006.
S. Li, D.Y. Fozdar, M. Ali, H. Li, D.B. Shao, M.G. Olsen, J. T. McDevitt, P.R.C. Gascoyne, S.C. Chen, “A Continuous-flow Polymerase Chain Reaction Microchip with Regional Velocity Control”, Journal of Microelectromechanical Systems, Vol. 15 (1), pp. 223- 236, 2006.
D. Y. Fozdar, S. Li, S. C. Chen, D. M. Vykoukal, J.V. Vykoukal, P.R.C. Gascoyne, T. Mautner, “Continuous-flow Polymerase Chain Reaction Chips for Rapid DNA Analysis”, Encyclopedia of Sensors, Vol. 1, pp 1-22, 2006.
C. A. Aguilar, Y. Lu, S. Mao, and S.C. Chen, “Micro-patterning of Biodegradable Polymers Using Ultraviolet and Femtosecond Lasers”, Biomaterials, Vol. 26 (36), pp. 7642-7649, 2005.
G. Mapili, Y. Lu, S.C. Chen, K. Roy, “Laser-layered Micro-fabrication of Spatially Patterned, Functionalized Tissue Engineering Scaffolds”, Journal of Biomedical Materials Research B, Vol. 75B (2), pp. 414-424, 2005.
Y. Lu, C. A. Aguilar, and S.C. Chen, “Shaping Biodegradable Polymers as Nanostructures: Fabrication and Applications”, Drug Discovery Today, Vol. 2 (1), pp. 97-102, 2005.
S. Li, P. N. Floriano, N. Christodoulides, D. Y. Fozdar, D.B. Shao, M. F. Ali, P. Dharshan, D. Neikirk, J. T. McDevitt, S. C. Chen, “Disposable Polydimethylsiloxane/Silicon Hybrid Chips for Protein Detection”, Biosensors and Bioelectronics, Vol. 21 (4), pp. 574-580, 2005.
Y. Lu and S. C. Chen, “Micro and Nano-fabrication of Biodegradable Polymers for Drug Delivery”, Advanced Drug Delivery Reviews, Vol. 56, pp. 1621-1633, 2004.
Y. C. Lee, B. Amirparviz, A Chiou, and S. C. Chen, “Packaging for Microelectromechanical and Nanoelectromechanical Systems”, IEEE Transactions on Advanced Packaging, Vol. 26 (3), pp. 217-226, 2003.
S. C. Chen, V. Kancharla, and Y. Lu, “Laser-based Microscale Patterning of Biodegradable Polymers for Biomedical Applications”, International Journal of Material and Product Technology, Vol. 18 (4), pp. 457-468, 2003.
V. Kancharla and S. C. Chen, “Fabrication of Biodegradable Polymeric Micro-devices Using Laser Micromachining.” Biomedical Microdevices, Vol. 4 (2), pp. 105-109, 2002.
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