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If you ask Dr. Marissa Nichole Rylander about the myriad factors influencing cancer cells, the names of dozens of growth-promoting proteins, signaling pathways, angiogenic factors and other players trip rapid-fire off her tongue. Undaunted by this biochemical brew, the tissue-engineering expert uses input from physicians at M.D. Anderson Cancer Center and ICES colleagues to create intricate simulations of tumors that are informing computational advances in the understanding of cancer.